Proteomics in Drug Discovery

It's the best time for Omics-series analysis in the therapeutic development, especially propelled by the movement of personalized medicine.

On one hand, we have an explosion of data and hence a new emerging understanding of complex biological systems. Information technology is also advancing rapidly as a catalyst. On the other, translation of the big data era methodologies into accelerated drug discovery and ultimate approval is still yet to be seen. I think we are on the cusp of that turnover.

Proteomics is large-scale study of proteomes. Proteome is an entire set of proteins that are produced or modified by an organism or system.

Proteome is not constant. It differs from cell to cell and changes over time. To some extent, proteome reflects the underlying transcriptome. However, protein activity is also modulated by many factors in addition to the level of protein expression.

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Proteomics is used to investigate: